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Description
human bsep vesicle kit hek293Das Human BSEP Vesicle Kit enthlt Inside out Membranvesikel aus HEK293 Zellen, die transient die Bile Salt Export Pump (BSEP ABCB11) berexprimieren. BSEP ist der primre hepatische Efflux Transporter fr Gallensalze und ein zentrales Zielprotein in der Risikoabschtzung fr medikamenteninduzierte Cholestase (DILI). Das Kit ist konform mit den FDA (2017) und EMA (2013) Leitlinien fr DDI Studien. Hergestellt von Cell4Pharma. Exklusiv im DACH Raum erhltlich
Das Human BSEP Vesicle Kit enthält Inside-out Membranvesikel aus HEK293-Zellen, die transient die Bile Salt Export Pump (BSEP / ABCB11) überexprimieren. BSEP ist der primäre hepatische Efflux-Transporter für Gallensalze und ein zentrales Zielprotein in der Risikoabschätzung für medikamenteninduzierte Cholestase (DILI). Das Kit ist konform mit den FDA (2017)- und EMA (2013) Leitlinien für DDI Studien.
Hergestellt von Cell4Pharma. Exklusiv im DACH-Raum erhältlich über SeamlessBio.
Transporter-Profil
Name: BSEP, Bile Salt Export Pump, ABCB11, ATP-bindende Kassette Unterfamilie B Mitglied 11
Gen: ABCB11
ATP/AMP-Ratio: >10 (garantiert)
Gewebsexpression: Kanalikuläre Plasmamembran der Hepatozyten
Erkrankungen: Erbliche und medikamenteninduzierte Cholestase (DILI)
Bekannte Substrate: Taurocholat, Pravastatin, Taurolithocholyl-3-Sulfat, konjugierte monovalente Gallensalze
In stock: Human, Katze, Hund
Kit-Inhalt (100 Reaktionen)
- Vesikel-Vial (100 Reaktionen), BSEP überexprimierende HEK293-abgeleitete Vesikel
- AMP-ATP-Lösung (100 mM), Cell4Pharma
- Assay-Puffer, Cell4Pharma
Anwendungen
- allensalztransport-Inhibitionsstudien (Cholestase-Risikoabschätzung)
- Drug-Induced Liver Injury (DILI) Screening
- Drug-Drug-Interaction-(DDI)-Studien gemäß FDA/EMA-Leitlinien
- Substratidentifikation für hepatische Efflux-Transporter
- High-Throughput-Screening (Radiolabel-, Fluoreszenz-, LC-MS-Detektion)
Regulatorische Konformität
Die Hemmung von BSEP ist ein etablierter Mechanismus der medikamenteninduzierten cholestatischen Leberschädigung. Die Bewertung der BSEP-Hemmung wird in den FDA (2017)- und EMA (2013)-DDI-Leitlinien als Teil des Transporter-Charakterisierungspakets für neue Molekülentitäten (NMEs) in der klinischen Entwicklung empfohlen.
Technische Spezifikationen
Wirtszelle: HEK293 (humane embryonale Nierenzelle)
Vesikeltyp: Inside-out-Membranvesikel
Format: 100 Reaktionen pro Kit
Detektion: Radiolabel / Fluoreszenz / LC-MS kompatibel
Lagerung: –80 °C
Verwandte Produkte
- Human Control Vesicle Kit (C4PVK009) – empfohlen als Negativkontrolle in BCRP-Transportassays
- Human MRP2 Vesicle Kit (C4PVK002) – for parallel hepatic efflux assessment
- Human BCRP Vesicle Kit (C4PVK006) – for complete efflux transporter panel
- ciPTEC-OAT1 Assay-Ready Cells – für zellbasierte Nephrotoxizitäts- und Transporterstudien
- Human Serum AB Male OTC (SeamlessBio) – zur Supplementierung von ciPTEC-Kulturmedien
Alle Produkte auf Anfrage.
Kontakt: [email protected] | Telefon: +49 851 37932226
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4.2 ★★★★★
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Product Reviews
★★★★★ 5
Feels great after cheap work soap hand washes
Size: 11 Fl Oz (Pack of 1)
This stuff is great. I reapply ALL the time because I have it at work.I wash my hands frequently and the soap at the work is very harsh, cheap, and generally just terrible on the skin.I use this after every wash and it leaves my hands and arms soft and moisturized. I have also received compliments on how nice my office smells after I apply it. While that might make it sound as if the scent is very strong, it isn't. It's nice, and lingers for a bit, but it is not overpowering or overwhelming. The tub goes a long way, and the container at my desk has lasted for months, and a little goes a long way. I appreciate that the container seals well and doesn't leak. Sometimes when I take other lotions on the go with me, I worry that the little flap top will open up and make a mess. That is not a problem with this jar AT ALL. It is easy to close and stays closed, even when I throw it in my bag and then throw my bag around a bit in transport.
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Reviewed in the United States on November 2, 2025
★★★★★ 5
A good buy a good price just a great product all the way around
Size: 11 Fl Oz (Pack of 1)
This product is a very good product I ran out too soon and need to order some more as soon as possible it does exactly what it says it will do and leaves your skin hydrated feeling great and not over greasy not a heavy product nice light and smells terrific
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Reviewed in the United States on May 20, 2026
★★★★★ 5
Soft, Glowing & Hydrated Skin ✨
Size: 11 Fl Oz (Pack of 1)
This body butter is amazing! It keeps my skin soft, smooth, and moisturized all day. The scent is light and beautiful, and it gives my skin a healthy glow without feeling greasy. Perfect for dry skin 😊
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Reviewed in the United States on May 12, 2026
★★★★★ 5
Wonderful for my super dry skin
Size: 11 Fl Oz (Pack of 1)
This moisturizer is great, I have no complaints. I have VERY dry skin and live in Chicago - where winters only make matters worse. This product has actually healed my dry, cracked skin and improved it's overall condition. It absorbs quickly and the scent is mild. I apply it after exfoliating in the shower at night and when I wake up, my skin is soft and looks healthy.
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Reviewed in the United States on January 25, 2026
★★★★★ 4
Great moisturizer
Size: 11 Fl Oz (Pack of 1)
Very creamy and does nicely as moisturizer on legs arms and especially after shower.
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Reviewed in the United States on May 23, 2026