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Description
Invivo anti-mouse PD-1 Recombinant mAb (RMP1-14)Product Specification Host Rat Antigen PD 1 Synonyms Programmed cell death protein 1, mPD 1, CD279 Immunogen N A Location Cell membrane Accession Q02242 Clone Number RMP1 14 Antibody Type Recombinant mAb Isotype Rat IgG2a, Isotype Control S0B0932 Application WB, ICC, SPR, In vivo blocking of PD 1 PD L signaling Reactivity Ms Purification Protein G Concentration 5 mg ml Endotoxin 1EU mg Tag N A Physical Appearance Liquid Storage Buffer PBS pH7. 4,
Product Specification
| Host | Rat |
| Antigen | PD-1 |
| Synonyms | Programmed cell death protein 1, mPD-1, CD279 |
| Immunogen | N/A |
| Location | Cell membrane |
| Accession | Q02242 |
| Clone Number | RMP1-14 |
| Antibody Type | Recombinant mAb |
| Isotype | Rat IgG2a, κ |
| Isotype Control | S0B0932 |
| Application | WB, ICC, SPR, In vivo blocking of PD-1/PD-L signaling |
| Reactivity | Ms |
| Purification | Protein G |
| Concentration | 5 mg/ml |
| Endotoxin | ＜1EU/mg |
| Tag | N/A |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, containing no preservative |
| Stability & Storage |
2 to 8 °C for 2 weeks under sterile conditions; -20 °C for 3 months under sterile conditions; -80 °C for 24 months under sterile conditions.
Please avoid repeated freeze-thaw cycles.
|
Dilution
| application | dilution | species |
| WB | 1:250 | |
| SPR | 2000nM-31.25nM | |
| ICC | 1:500 |
Background
Programmed cell death protein 1, also known as PD-1 and CD279 (cluster of differentiation 279), is a protein on the surface of T and B cells that has a role in regulating the immune system's response to the cells of the human body by down-regulating the immune system and promoting self-tolerance by suppressing T cell inflammatory activity. This prevents autoimmune diseases, but it can also prevent the immune system from killing cancer cells. PD-1 is an immune checkpoint and guards against autoimmunity through two mechanisms. First, it promotes apoptosis (programmed cell death) of antigen-specific T-cells in lymph nodes. Second, it reduces apoptosis in regulatory T cells (anti-inflammatory, suppressive T cells).
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