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Description
GARP&Latent TGF-β1 Heterotrimer His Tag Protein, MouseProduct Specification Species Mouse Synonyms RRC32 & TGF beta 1; LRRC32&TGFB1 Accession G3XA59P04202 Amino Acid Sequence GARP: Ile18 Asn628, with C terminal His Latent TGF 1: Leu30 Ser390 Expression System HEK293 Molecular Weight 80 93kDa GARP(Reducing), 35 50kDa LAP(Reducing), 10 14kDa mature TGF 1 (Reducing) Purity 95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7.
Product Specification
| Species | Mouse |
| Synonyms | RRC32 & TGF-beta 1; LRRC32&TGFB1 |
| Accession | G3XA59、P04202 |
| Amino Acid Sequence | GARP: Ile18-Asn628, with C-terminal His Latent TGF-β1: Leu30-Ser390 |
| Expression System | HEK293 |
| Molecular Weight | 80-93kDa GARP(Reducing), 35-50kDa LAP(Reducing), 10-14kDa mature TGF-β1 (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4. |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage |
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1. Alessandra Metelli, Mohammad Salem, Caroline H Wallace, Bill X Wu, Anqi Li. Immunoregulatory functions and the therapeutic implications of GARP-TGF-β in inflammation and cancer. J Hematol Oncol. 2018 Feb 20;11(1):24. |
Background
GARP (glycoprotein-A repetitions predominant) is a type I transmembrane cell surface docking receptor for latent transforming growth factor-β (TGF-β) that is abundantly expressed on regulatory T lymphocytes and platelets. By binding to LTGF-β, GARP acts as a docking receptor that concentrates LTGF-β on the cell surface and enhances its final activation. The function of GARP has been extensively studied on regulatory T lymphocytes (Tregs), where it complexes with αVβ8 integrins to release active TGF-β from the surface of the cells. Via this function, GARP was shown to be involved in enhancing the suppressive phenotype of Tregs and in maintaining Treg-mediated peripheral tolerance.
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4.8 ★★★★★
Based on 1067 reviews
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Product Reviews
★★★★★ 5
Amazing!
Format: Kindle, Format: Kindle
This book was phenomenal, I devoured it within a few days! For this being a debut novel, it is fantastic and I would’ve thought the author was a seasoned author. I have zero complaints about this book.
Let me start by saying that the world building was phenomenal. I could picture everything in my head because of how detailed it was — that’s how good it was written. And I absolutely love the “captive/captor” trope so much, it’s become one of my favorite tropes, so I was pleasantly surprised to see that this book had that.
I loved the banter between Rogue and Ara — they’re both snarky and witty, plus with the romantic tension, it made the dialogue that much better. Speaking of romantic tension, yes there is spice but not so much of it that it overrides the plot, which I loved. For me, this would probably be on the 3/5 level of spice.
This book had a ton of plot twists and I thoroughly enjoyed it.
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Reviewed in the United States on November 13, 2024
★★★★★ 4
High on Tropes and Satisfaction
Format: Kindle
This is a great Romantasy book full of action, adventure, and everything you look for in this genre.
I won’t lie: it does kinda feel like the author found every common trope from every successful book of this kind and threw them all into this novel. But if it ain’t broke, don’t fix it. Especially in romance, there’s a large audience who has specific expectations, and they want them every time. Nothing wrong with that and many times I’m one of them.
I have no idea what defines a spoiler honestly, so
spoiler alert!!!!!!!
Tropes include:
Only one bed at the inn/bar
Dissatisfaction with life before hunk appears
Lost royalty
The chosen one
Montage of dress up time followed by shocked hunk
Forbidden romance between two from rival peoples
Power that cannot be controlled, simply guided/asked
Gathering intel at the inn/bar
FMC who knows how to fight/use weapons well
There’s probably more but no need to list them all.
Good story and I would recommend!
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Reviewed in the United States on June 14, 2024
★★★★★ 5
☕️The need to claim her, mark her, break her, seared through me like white fire🎨
Format: Kindle
"Some trauma stuck with you and Kaleb's had fused itself to his bones like a demented shadow. Rearing it's ugly head whenever it got hungry, feasting on whatever stability he'd managed to regain since it's last meal."
"The need to claim her, mark her, break her, seared through me like white fire."
"I shivered at his touch, expecting to find disgust in his stare, but finding something else instead. Wonder. And something else. A sort of recognition that could only come from someone who knew the same level of pain. Of fear for their own life."
"In a moment of clarity, I realized I knew why a good guy would never be enough. Good guys didn't touch you like bad guys did. They didn't push the limits. Hold you down. Make you insane with need. Make you scream."
"I figured Becca was like a bad habit. All I needed to do was resist her long enough and I'd be free. I didn't want to be free. I needed to be free."
"Like he was waiting patiently for me to come to him, like he knew he didn't have to chase me anymore. Back to being my Mr. Dark and Gloomy. No. Not my. Never mine."
"Let the panic consume you. Accept it or else it'll never let you go. And then remember, you are stronger than you think you are."
Yes! This first book was everything. I have been very curious about Becca and her new love interests since I read The Crows series. This was packed full of action and the plot has me fully invested. The spice was spicin 🔥🔥🔥. The characters were fleshed out fully as well. This one left on a cliffhanger and I wanted to punch Aodhan. Although secretly my heart breaks for him 😂😭.
This follows Becca as she moved to CA and is attending Calarts. Her father cut her off, she has no money, so she has to start over by herself. She ends up running into Hardin and Kaleb who are brothers and cousins to the Saints from the crows series. Becca, while attracted to them, hates them as she blames their father for her mother's death. Meanwhile she meets another stranger named Aodhan who wants to take her on a date. Who is this mysterious Irishman? While Hardin and Kaleb are the kings and rule the LA area, a new Irish gang is trying to take their turff. Secrets are unleashed regarding Becca's past. Lives are lost. A war is breaking out. Secret identities are in the mist. Who will survive in this duet?
I always loved Becca from the other series. She has been through a lot and she's still healing from those events. You could see her growth in this first book. I love her fiery and badass self. Kaleb is a golden retriever and ray of sunshine when he's not stuck in his trauma. I love how outgoing and funny he is. His brother Hardin is the opposite. He doesn't talk. He's very angry and doesn't take crap from anyone. Aodhan is a mystery. He seems sweet and chill but also extremely broken. All of these men and Becca have heavy trauma going on. The spicy scenes between her and the brothers was so hot 🔥🔥🔥. They had insane chemistry 🥵. I'm curious how Aodhan will be added.
I loved seeing cameos from the crows and Ava! I hope we get to see more of them in the next book. I love how Sloane is such a fierce badass. The women in this series are just fantastic. Damien is a strong character and I'm excited to see how that unfolds. I also love Becca's new roommates. Onto the next book!
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Reviewed in the United States on January 24, 2026
★★★★★ 4
Soulless Saint
Format: Kindle
This is a spinoff featuring Becca, Hardin and Kaleb. You don't need to read the other Elena Lawson series to read this one. I didn't and I understood the plot easily. Becca is struggling to get back on her feet after her dad cuts her off. She finds a job and roommates and keeps bumping into Kaleb and Hardin. They are members of The Saints, Santa Clarita chapter. Their cousins are from the Thorn Valley chapter featured in the other series. Hardin is silent but deadly whereas Kaleb is battling demons and the world knows it. They've been asked to look after Becca, unbeknownst to her but they get too close and become obsessed with her. None of them can stay away from each other which puts Becca and danger from The Saints enemies. Can she survive more gang life violence? Becca wants to stay away but their chemistry is undeniable. This book has lots of violence and lots of passion. It's a thrill ride from beginning to end.
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Reviewed in the United States on January 29, 2023
★★★★★ 5
Soulless Saint
Format: Kindle
If you're looking for a dark, thrilling romance that will keep you on the edge of your seat, "Soulless Saint" by Elena Lawson is the book for you. This first installment in the Kings of Kilborn University dseries is an irresistible mix of passion, danger, and intense chemistry.
The story follows Becca, who moves to a new city to escape her past, only to find herself entangled with Kaleb and Hardin, crime lords known as the Sainted Kings. Initially tasked with protecting her, their relationship quickly evolves from animosity to an obsessive attraction that neither can resist.
Becca is our fiery fmc and she is trying to rebuild her life after being cut off by her father. Kaleb and Hardin are complex and compelling—Kaleb is haunted by his own demons, while Hardin is the silent, deadly type. Their interactions with Becca are electrifying, filled with tension and undeniable chemistry.
The book is packed with steamy scenes, raw violence, and unexpected twists that will leave you breathless. Just when you think you know where the story is going, Lawson throws in surprises that keep you hooked. The introduction of Aódhan, a mysterious and captivating character - needing more of him.
"Soulless Saint" is a fast-paced, gripping read that you won't be able to put down. If you love dark romance with multifaceted characters and high stakes, this book is a must-read. The ending will leave you eagerly anticipating the next book.
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Reviewed in the United States on June 19, 2024
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