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Description
IFN-α 1b Protein, HumanProduct Specification Species Human Synonyms Interferon 1b, IFN 1b, Interferon alpha 1 13 Accession P01562 Amino Acid Sequence Cys24 Glu189 Expression System E. coli Molecular Weight 18 19 kDa (Reducing) Purity >95% by SDS PAGE. Endotoxin <1EU g Conjugation Unconjugated Tag No Tag Physical Appearance Lyophilized Powder Storage Buffer 20mM Tris, 150mM NaCl, 1mM TCEP, pH8. 0 Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure
Product Specification
| Species | Human |
| Synonyms | Interferon-α1b, IFN-α 1b, Interferon alpha-1/13 |
| Accession | P01562 |
| Amino Acid Sequence | Cys24-Glu189 |
| Expression System | E.coli |
| Molecular Weight | 18-19 kDa (Reducing) |
| Purity | >95% by SDS-PAGE. |
| Endotoxin | <1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | 20mM Tris, 150mM NaCl, 1mM TCEP, pH8.0 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | ·12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | Blood. 2021 Sep 30;138(13):1162-1171. |
Background
IFN-α is a cytokine that has an immunomodulatory function. It plays an important role not only in antiviral activity but also in several physiologic functions, such as activation of dendritic cells and accelerated expression of major histocompatibility complex I and II molecules that may cause increased antigen presentation. Many IFN-alpha subtypes differ in their sequences at only one or two positions. Among the 13 subtypes of human IFNalpha, IFNalpha-1 subtype has 2 variants, named IFN-α 1a and IFN-α 1b, that differ from each other in only 1 amino acid, at residue 114. This cytokine, like other type I interferons, binds a plasma membrane receptor made of IFNAR1 and IFNAR2 that is ubiquitously expressed, and thus is able to act on virtually all body cells. IFN-α is upregulated in preeclamptic placentas and is thought to be a mediator of preeclampsia.
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