SKU: 70960147026

CD117/c-Kit Fc Chimera Protein, Mouse

Sale price$124.20 Regular price$138.00
Save 10%

Pay in installments of $34.50 with ShopPay, AfterPay and Klarna

Shipping Estimate
USA
  • USA
  • CAN

Ships within 48 hours · Estimated delivery Jul 23 - Jul 28

Promo Codes Available:

For Your Every Summer RSVP, with Code: SUMMER15

Description

CD117/c-Kit Fc Chimera Protein, MouseProduct Specification Species Mouse Synonyms CD117 antigen; CD117; ckit; c kit; EC 2. 7. 10; EC 2. 7. 10. 1; KIT; PBT; piebald trait; Proto oncogene c Kit; proto oncogene tyrosine protein kinase Kit; SCF R; SCFR; SCFRmast stem cell growth factor receptor; soluble KIT variant 1; Tyrosine protein kinase Kit; v kit Hardy Zuckerman 4 feline sarcoma viral oncogene homolog; v kit Hardy Zuckerman 4 feline sarcoma viral oncogene like protein Accession P05532

Product Specification


Species Mouse
Synonyms CD117 antigen; CD117; ckit; c-kit; EC 2.7.10; EC 2.7.10.1; KIT; PBT; piebald trait; Proto-oncogene c-Kit; proto-oncogene tyrosine-protein kinase Kit; SCF R; SCFR; SCFRmast/stem cell growth factor receptor; soluble KIT variant 1; Tyrosine-protein kinase Kit; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein
Accession P05532-2
Amino Acid Sequence Ser25-Pro523, with C-terminal His
Expression System HEK293
Molecular Weight 95-120kDa (Reducing)
Purity >95% by SDS-PAGE & >95% by SEC-HPLC
Endotoxin <0.1EU/μg
Conjugation Unconjugated
Physical Appearance Lyophilized Powder
Storage Buffer PBS, PH7.4, 5% trehalose
Reconstitution Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Reference


1.Kimura, Y. et al. (2011) PLoS ONE 6:e26918. 2.Tallini, Y.N. et al. (2009) Proc. Natl. Acad. Sci. USA 106:1808. 3.Bashamboo, A. et al. (2006) J. Cell Sci. 119:3039. 4.Sun, L. et al. (2004) J. Clin. Invest. 113:1364.

Background

Stem Cell Factor Receptor (SCF R), also known as c-Kit and CD117, is a widely expressed 145 kDa receptor tyrosine kinase. It is the cellular homolog of the feline sarcoma virus protein, v-Kit. Binding of SCF R to SCF, also known as Steel Factor and Kit Ligand, promotes the survival, differentiation, and mobilization of progenitor cells in multiple lineages. Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1.

Shipping Notes
  • Free Standard Shipping on $100+ Orders to the USA.
  • Except Preorder products are shipped in 48 hours.
  • Delivery to the USA:
  1. Standard Shipping : 3-10 business days
  • If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
  • We offer a 30-day return/exchange service after receiving.
  • Final sale items are not eligible for returns or exchanges.
  • To process your return/exchange, please contact us at [email protected]
  • Please click here for more details>>> Return & Exchange Policy
SKU: 70960147026

Discover Niche Categories That Outsell

Top-Converting Item to Boost Your Average Order

4.5 ★★★★★
Based on 6 reviews
Sort
Highest Rating
Newest First
Oldest First
Product Reviews
C
Verified Purchase
Chris S.
Carnegie, US
★★★★★ 5
Works great and attractive
Works great, easy to use and attractive. Lightweight, doesn't take up a lot of space. Battery seems strong. Foil cutter works great. Good buy!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 12, 2026
A
Verified Purchase
Amy C
New York, US
★★★★★ 5
GREAT product!
I have had mechanical wine openers before and found them to be more annoying and more time consuming than just using a traditional corkscrew. NOT the case w/this one. So.... 1. display: the charger station is small enough in size that it would fit in most any location w/o taking up too much space. For those that do not like clutter or one more "gadget" to sit out, this is a good size. The charging station has a little holder for the foil cutter as well which is great and keeps all parts together so no one has to search drawers when ready to open the bottle. There is a blue light that glows while being charged and is very pleasant to look actually and is a nice touch. so it actually looks really good sitting on top of the wine rack. Mine happens to be right next to an electrical plug on the wall so does not reveal the hanging cords or wires. 2. function: works great so far and have opened quite a few bottles. very easy to use. would suggest holding the bottle by the fatter part toward the middle and then using the other hand to work the corkscrew. does not work well if the bottle sits on the counter unless you have a good solid grip on the base. Its actually easier to just pick up the bottle and do it that way. of course that's after using the foil cutter which gives a perfect cut and removal each and every time. 3. battery life: i think the product says it can be used for 30 bottle openings during a single charge. that is quite more wine that most people would be going through in an evening so i don't think anyone would have an issue w/keeping a charge. I use it and then put directly back on the charging station as i do my mechanical salt and pepper grinders. that way, its always on the cradle and charging. as mentioned there is a blue light that glows in the actual item while its charging and i like the way it looks so would have no reason to keep it off the charger anyway. this also makes a GREAT gift especially a house warming gift to anyone who drinks wine or entertains
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on October 14, 2020
A
Verified Purchase
Amazon Customer
Birmingham, US
★★★★★ 5
Wine opener.
Works great.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on June 4, 2026
J
Verified Purchase
Jenni
Waukegan, US
★★★★★ 4
Great but had a problem
It’s great except you have to finagle the darn thing for it to charge. Sometimes I have to use something to get it to lean just right so it charges. Otherwise it’s spectacular and easy to use! Love the foil cutter tbh, that works like a gem!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 26, 2026
D
Verified Purchase
Denyce Schoemehl
New York, US
★★★★★ 5
Got it fast and works great
Very nice looking and works fast!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on June 9, 2026

recommand products