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Description
Anti-Gulgafafusp alfa Monoclonal Antibody (Glutazumab)Product Specification Host Human Antigen Gulgafafusp alfa Antibody Type Recombinant mAb Reactivity Hu Purification Protein A Concentration 2 mg ml Endotoxin <1EU mg Physical Appearance Liquid Storage Buffer PBS pH7. 4, containing no preservative Stability & Storage 2 to 8 C for 2 weeks under sterile conditions; 20 C for 3 months under sterile conditions; 80 C for 24 months under sterile conditions. Background Gulgafafusp alfa is a humanized IgG2
Product Specification
| Host | Human |
| Antigen | Gulgafafusp alfa |
| Antibody Type | Recombinant mAb |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Endotoxin | <1EU/mg |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, containing no preservative |
| Stability & Storage | 2 to 8 °C for 2 weeks under sterile conditions; |
Background
Gulgafafusp alfa is a humanized IgG2κ monoclonal antibody fusion protein targeting the glucagon-like peptide-1 receptor (GLP-1R) for the treatment of type 2 diabetes mellitus and obesity. This protein is engineered through genetic fusion of a GLP-1(7-35) agonist fragment to the Fc region of an anti-GLP-1R antibody, forming a unique "antibody-ligand" bifunctional structure: the antibody moiety specifically binds to GLP-1R, while the GLP-1 fragment activates downstream cAMP signaling pathways. Through synergistic dual receptor binding sites, this design significantly enhances binding affinity and prolongs half-life. As a long-acting GLP-1R agonist, Gulgafafusp alfa promotes glucose-dependent insulin secretion, suppresses glucagon release, delays gastric emptying, and increases satiety, thereby achieving sustained glycemic control and weight reduction effects.
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