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Description
Biotinylated EGFRvIII His&Avi Tag Protein, HumanProduct Specification Species Human Synonyms EGFRvIII, ERBB, ERBB1, HER1, mENA, NISBD2, PIG61 Accession NP_001333870. 1 Amino Acid Sequence Leu25 Ser378, with C terminal His and Avitag Expression System HEK293 Molecular Weight 60 75kDa (Reducing) Purity 95% by SDS PAGE Endotoxin <1EU g Conjugation Biotin Tag Avi Tag, His Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4. Reconstitution Reconstitute at 0. 1 1 mg ml according to the
Product Specification
| Species | Human |
| Synonyms | EGFRvIII, ERBB, ERBB1, HER1, mENA, NISBD2, PIG61 |
| Accession | NP_001333870.1 |
| Amino Acid Sequence | Leu25-Ser378, with C-terminal His and Avitag |
| Expression System | HEK293 |
| Molecular Weight | 60-75kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Conjugation | Biotin |
| Tag | Avi Tag, His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4. |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1. Hui K. Gan,The epidermal growth factor receptor variant III (EGFRvIII):where wild things are altered,the FEBS journal,Received 2 April 2013, revised 10 June 2013, accepted 13 June 2013 |
Background
The epidermal growth factor receptor (EGFR) is overexpressed in a variety of human epithelial tumors, often as a consequence of gene amplification. Tumors with EGFR gene amplification frequently contain EGFR gene rearrangements, with the most common extracellular domain mutation being EGFRvIII. This mutation leads to a deletion of exons 2–7 of the EGFR gene and renders the mutant receptor incapable of binding any known ligand. Despite this, EGFRvIII displays low-level constitutive signaling that is augmented by reduced internalization and downregulation. Aberrant EGFRvIII signaling has been shown to be important in driving tumor progression and often correlates with poor prognosis. It is clear that EGFRvIII is expressed in a considerable proportion of patients with glioblastoma multiforme (GBM). The presence of EGFRvIII in other tumor types, however, remains controversial.
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4.5 ★★★★★
Based on 615 reviews
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Product Reviews
★★★★★ 5
soft finish for upper lip and chin area
I pay close attention to fine facial hair, especially around my upper lip and chin area. Under strong lighting, those small hairs can appear more visible, so I have been looking for a gentle way to care for this area without anything harsh or overly complicated. At night, after cleansing my face and completing my basic skincare, I apply this oil as the final step. It feels like a light finishing layer over the skin. I use a very small amount, about one or two drops, warm it between my fingertips, then gently press it onto the upper lip and chin area. There is no stinging sensation, and the scent is very mild, which makes the application feel calm and comfortable. The texture feels lighter than expected. It spreads smoothly and settles quickly without leaving a heavy or greasy film. My skin type leans slightly combination, and in my case it sits well without making the T zone feel overly coated. Even when I follow with a light moisturizer, it layers without pilling and still feels breathable on the skin. After using it regularly every three days in the evening, the change I notice is mainly visual. The fine facial hair looks less pronounced under bright lighting, especially around the upper lip area. The skin surface also appears more even, and when I touch it, it feels smoother and less uneven in texture. These changes feel gradual rather than sudden, becoming more noticeable over time. From a makeup perspective in the morning, my base applies more evenly after cleansing. Foundation tends to sit more smoothly around the chin and upper lip area, without clinging to texture. During humid days, the skin can feel slightly more active in oil balance, but the overall finish still looks even and natural once makeup is applied.
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Reviewed in the United States on April 10, 2026
★★★★★ 5
Good for maintaining clean beard lines
I keep my beard trimmed, but I always have to clean up the edges along my neckline to keep it looking neat. Lately, I've been massaging a few drops of this natural oil into my neck on Tuesday mornings right after I finish shaving at the sink. It feels really soothing on freshly shaved skin, kind of acting like a light daily moisturizer.
The bottle is only 1.85 ounces, but you only need a tiny dab to cover a small area so it should last a while. Over the last month, the stubble along my collar line definitely feels softer, and it takes an extra day or two before it starts looking messy again. If you trim your own facial hair and want to stretch out the time between touching up your neck or cheek lines, this is handy to keep by the mirror.
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Reviewed in the United States on May 21, 2026
★★★★★ 5
Gentle Oil for After Hair Removal Care
I started using this Cyperus oil after shaving because my skin often feels dry afterward. The texture is lightweight and spreads easily, so I only need a small amount on areas like legs and underarms. I usually apply it after showering, when my skin is clean and dry, then massage it in for a few minutes. The oil feels soothing and gives my skin a softer, more moisturized feeling without being too greasy. It absorbs better than I expected, especially when I use a thin layer. The scent is mild and does not bother me during daily use. For unwanted hair care, I know it is not something that shows a big change overnight, so I use it consistently after hair removal. It has been easy to add into my routine, and I like that it helps calm and moisturize my skin after shaving or waxing.
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Reviewed in the United States on May 13, 2026
★★★★★ 5
Skincare and Hair Care Experience with This Cyperus Rotundus Oil
This cyperus rotundus oil has a lightweight texture with good fluidity, it absorbs quickly when applied to the face, leaving no greasy or heavy feeling, even for combination-oily skin, I mainly use it for facial moisturizing and body care, after washing my face, I warm 2-3 drops in my palms and press it into my skin, and it doesn’t cause pilling when applying makeup afterward, leaving my skin soft and smooth, for hair care, after using it consistently for a month, the hair on my underarms and limbs has become finer, and the growth rate has slowed down significantly, so I don’t need to remove hair frequently, my skin also doesn’t get rough from frequent shaving, there’s no stinging or burning sensation during use, making it safe for sensitive skin, and the light aloe scent is fresh and pleasant, the dropper design is convenient, allowing precise dosage control to avoid waste, in addition to face and body, I also use it for scalp care, after washing my hair, I massage a few drops into my scalp, which relieves dryness and makes my hair smoother and shinier, overall, it delivers noticeable results for both skincare and hair care, with a comfortable user experience.
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Reviewed in the United States on April 10, 2026
★★★★★ 5
Absorbs into the skin well and no irritation so far
I bought this Cyperus Rotundus oil to try out, and the 1.85 oz bottle is a good size for me. The oil has a light botanical scent that is pleasant and not too strong. I have applied it a few times and found that it is very easy to use with the included dropper. It absorbs into the skin well and I have noticed no irritation at all, which is important for my daily routine.
The bottle arrived quickly and was packaged securely so there were no leaks. It is a practical addition to my shelf, and the glass container feels solid. This product does exactly what it says on the label and provides a straightforward way to use a natural oil. It is a functional and simple purchase that meets my needs perfectly.
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Reviewed in the United States on April 25, 2026